Domino first attracted national attention with "The Fat Man" in 1949 on Imperial Records. This song is an early rock and roll record, featuring a rolling piano and Domino doing "wah-wah" vocalizing over a strongback beat. It sold over a million copies and is widely regarded as the first rock and roll record to do so.
Fats Domino released a series of hit songs with producer and co-writer Dave Bartholomew,saxophonists Herbert Hardesty and Alvin "Red" Tyler and drummer Earl Palmer. Other notable and long-standing musicians in Domino's band were saxophonists Reggie Houston, Lee Allen, and Fred Kemp, Domino's trusted bandleader. Domino finally crossed into the pop mainstream with "Ain't That a Shame" (1955), which hit the Top Ten, though Pat Boone characteristically hit #1 with a milder cover of the song that received wider radio airplay in a racially-segregated era. Domino eventually had 37 Top 40 singles.
Domino's first album, Carry on Rockin', was released under the Imperial imprint, #9009, in November 1955 and subsequently reissued asRock and Rollin' with Fats Domino in 1956. Combining a number of his hits along with some tracks that had not yet been released as singles, the album went on under its alternate title to reach #17 on the "Pop Albums" chart.
His 1956 up-tempo version of the 1940 Vincent Rose, Al Lewis & Larry Stock song, "Blueberry Hill" reached #2 in the Top 40, was #1 on the R&B charts for 11 weeks, and was his biggest hit. "Blueberry Hill" sold more than 5 million copies worldwide in 1956-57. The song had earlier been recorded by Gene Autry, and Louis Armstrong among many others. He had further hit singles between 1956 and 1959, including "When My Dreamboat Comes Home" (Pop #14), "I'm Walkin'" (Pop #4), "Valley of Tears" (Pop #8), "It's You I Love" (Pop #6), "Whole Lotta Loving" (Pop #6), "I Want to Walk You Home" (Pop #8), and "Be My Guest" (Pop #8).
Domino appeared in two films released in 1956: Shake, Rattle & Rock! and The Girl Can't Help It. On December 18, 1957, Domino's hit "The Big Beat" was featured on Dick Clark's American Bandstand.
On November 2, 1956, a riot broke out at Fats Domino's show in Fayetteville, NC, with police resorting to tear gas to break up the unruly crowd. Domino jumped out of a window to avoid the melee; he and two other band members were slightly injured.Fayettevile, NC 11-02-1956
Domino continued to have a steady series of hits for Imperial through early 1962, including "Walkin' to New Orleans" (1960) (Pop #6), co-written by Bobby Charles, and "My Girl Josephine" (Pop #14) from the same year. After Imperial Records was sold to outside interests in early 1963, Domino left the label: "I stuck with them until they sold out," he claimed in 1979. In all, Domino recorded over 60 singles for the label, placing 40 songs in the top 10 on the R&B charts, and scoring 11 top 10 singles on the pop charts. Twenty-two of Domino's Imperial singles were double-sided hits.
from: http://en.wikipedia.org